منابع مشابه
Recursive domains in proteins.
The domain is a fundamental unit of protein structure. Numerous studies have analyzed folding patterns in protein domains of known structure to gain insight into the underlying protein folding process. Are such patterns a haphazard assortment or are they similar to sentences in a language, which can be generated by an underlying grammar? Specifically, can a small number of intuitively sensible ...
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In a series of articles, we developed a method to translate general recursive functions written in a functional programming style into constructive type theory. Three problems remained: the method could not properly deal with functions taking functional arguments, the translation of terms containing λ-abstractions was too strict, and partial application of general recursive functions was not al...
متن کاملIdentifying structural domains in proteins.
Analysis of protein structures typically beginswith decomposition of the structure intomore basic units called structural domains. The underlying goal is to reduce a complex protein structure to a set of simpler, yet structurallymeaningful units, each ofwhich can be analyzed independently. Structural semi-independence of domains is their hallmark: domains often have compact structure that can f...
متن کاملDisorder in membrane proteins cytoplasmic domains
Bioinformatic analyses have highlighted an overrepresentation of intrinsic disorder in the intracellular domains of membrane proteins. We have addressed the role of intrinsic disorder in two membrane proteins, the human sodium-proton exchanger 1 (NHE1), a 12 TM-helix protein and the human prolactin receptor (PRLR), which has a single-pass TM-helix. NHE1 and PRLR contain long (<300 residues) int...
متن کاملModular binding domains in signal transduction proteins
The transduction of a signal is a change in form of the signal as it is passed from one carrier to another. The root "duce" means"to lead" in Latin; thus, a signal is led through a cell by steps of transduction (the same root is in the words seduce and duct as well as II Duce). The earliest transduction steps that were elucidated involved massive release of small molecule "second messengers", o...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2009
ISSN: 0961-8368
DOI: 10.1110/ps.24701